South Asian Journal of Cancer

HISTOPATHOLOGY IN ONCOLOGY: ORIGINAL ARTICLE
Year
: 2015  |  Volume : 4  |  Issue : 1  |  Page : 32--34

Cytological grading of breast carcinoma on fine needle aspirates and its relation with histological grading


Jyoti Prakash Phukan1, Anuradha Sinha1, Jatindra Prasad Deka2 
1 Department of Pathology, Bankura Sammilani Medical College, Bankura, West Bengal, India
2 Department of Pathology, Tezpur Medical College, Tezpur, Assam, India

Correspondence Address:
Anuradha Sinha
Department of Pathology, Bankura Sammilani Medical College, Bankura, West Bengal
India

Background: Grading of breast carcinoma on fine needle aspiration cytology (FNAC) is beneficial for selecting patients for neoadjuvant chemotherapy. Aims: To grade the breast carcinoma on FNAC using Robinson grading system and to assess the concordance of cytological grading (CG) with histological grading (HG) using Elston-Ellis modification of Scarff-Bloom-Richardson grading system. Materials and Methods: The study was conducted for 1-year, comprising of 50 female patients attending outpatient departments (OPD) as well as admitted in various surgical wards of a teaching hospital, diagnosed as breast carcinoma. FNAC smears were stained with May-Grunwald-Giemsa and Papanicolaou (Pap) stains and CG was done using Robinson system on Pap stained smears. The results were compared with HG system after resection of tumors. Results: Of 50 cases, 14 (28%) cases were graded as grade I, 24 (48%) grade II, and 12 (24%) grade III by CG, whereas 9 (18%), 28 (56%) and 13 (26%) cases were graded as grade I, II and III by HG. The result showed overall 72% concordance of CG with HG, with grade II and grade III showing highest degree of concordance (83.33%), which is comparable to previous studies. Kappa measurement showed a higher degree of agreement in high-grade tumors compared with low-grade tumors (0.73 in grade III, 0.53 in grade II and 0.39 in grade I). Conclusion: Cytological grading is comparable to HG in majority of cases. Because neoadjuvant chemotherapy is becoming increasingly popular as primary treatment modality of breast cancer, CG could be a useful parameter in selecting the mode of therapy and predicting tumor behavior.


How to cite this article:
Phukan JP, Sinha A, Deka JP. Cytological grading of breast carcinoma on fine needle aspirates and its relation with histological grading.South Asian J Cancer 2015;4:32-34


How to cite this URL:
Phukan JP, Sinha A, Deka JP. Cytological grading of breast carcinoma on fine needle aspirates and its relation with histological grading. South Asian J Cancer [serial online] 2015 [cited 2019 Dec 7 ];4:32-34
Available from: http://journal.sajc.org/article.asp?issn=2278-330X;year=2015;volume=4;issue=1;spage=32;epage=34;aulast=Phukan;type=0